2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure activity relationship and mode of action studies.
the publish article garnerd much attention as a medical breakthrough for assesing the effectiveness of some 20 compounds determing their potenial as antimalarial drugs testing their toxicity and binding eficancy against two strains of Plasmodium Flaciparum, 3D7 a drug resistant strain and K1 a drug sensitive strain. the researchers also determind methods of synthesis and potential yeild(1)
4.1 the final steps in producing 2-Aminopyrimidine based 4-aminoquinoline
1. Kamaljit Singh, Hardeep Kaur, Kelly Chibale, Jan Balzarini, Susan Little, Prasad V. Bharatam, 2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure–activity relationship and mode of action studies, European Journal of Medicinal Chemistry, Volume 52, June 2012, Pages 82-97, ISSN 0223-5234, 10.1016/j.ejmech.2012.03.007.